LIPID PEROXIDATION OF MEMBRANES IN RENAL ISCHEMIA

Abstract

Renal ischemia causes tissue hypoxia and activation of reactive oxygen species, which leads to damage to cell membranes through lipid peroxidation (LPO) processes. This study examines changes in malonic acid levels. Dialdehyde (MDA) levels and antioxidant enzyme activity (SOD, catalase, glutathione peroxidase) in renal ischemia. It was shown that ischemia is accompanied by a significant increase in oxidative stress and a weakening of antioxidant defenses, leading to damage to tubular cell membranes, impaired microcirculation, and increased blood viscosity. The results highlight the key role of oxidative stress in the pathogenesis of ischemic kidney injury and the need for oxidative stress correction for prevention and treatment.