HISTOGENESIS OF THE CARDIOVASCULAR SYSTEM IN PATIENTS WITH HEART FAILURE
Keywords:
Heart failure, histogenesis, cardiomyocytes, myocardial remodeling, endothelium, fibrosis, angiogenesis, extracellular matrix.Abstract
Heart failure (HF) is a complex clinical and pathophysiological syndrome characterized by the inability of the heart to provide adequate blood flow to meet the body's metabolic needs. Structural changes in HF are caused by disturbances in histogenesis and remodeling of cardiovascular tissues. This article examines the embryonic development of the cardiovascular system, as well as changes in cellular differentiation, regeneration, and intercellular interactions in heart failure. Particular attention is paid to the role of cardiomyocytes, endothelial cells, fibroblasts, and the extracellular matrix in disease progression.
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